Academic Press, 2019. — 349 p. — (History of Toxicology and Environmental Health). — ISBN: 978-0-12-813697-3. This book uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health...
Humana Press 2014. — 585 p. European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), Systems Toxicology Unit, Institute for Health and Consumer Protection, Joint Research Centre, European Commission, Ispra (VA), Italy Paul Jennings Division of Physiology, Department of Physiology and Medical Physics, Innsbruck Medical University, Innsbruck, Austria...
John Wiley and Sons, 2019. — 322 p. — ISBN: 978-1-119-06026-0 Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets. Introduction to cellular signal transduction: The connection between a biological system and its surroundings Mechanisms of...
Springer, 2022. — 205 p. This book focuses on the principles, methods, and interpretation involved in establishing the safety, risk, and hazard assessment of small molecules. It presents the regulatory requirements for risk and hazard identification as per the guidelines of the Organization for Economic Cooperation and Development (OECD), Paris, and the International Council...
John Wiley & Sons, 2005. - 2759 p. ISBN: 0-471-24106-7. Current Protocols in Toxicology is a "best-practices" collection of lab protocols for accurate, efficient assessments of toxicity in whole organisms, organs and tissues, cells, and biochemical pathways. Continuously updated since its initial publication in May 1999, this quarterly-updated two-volume set. provides the...
2nd Edition. — The Royal Society of Chemistry, UK, 2017. — 610 p. — (Issues in Toxicology No. 30) — ISBN: 178262287X.
Concerns about the adverse effects of chemicals present in the environment have created a need for better systems to assess their potential consequences on human health. One potential solution is the versatile and state-of-the-art Comet assay. Simple, sensitive,...
Published by The Royal Society of Chemistry, 2009. — 477 p. This book is the first of its kind to be devoted exclusively to the Comet assay and its applications as an important tool in current toxicology. This multiauthor book will serve as both a reference and a guide for investigators in the biomedical, biochemical and pharmaceutical sciences. Specialists from the fields of...
Academic Press, 2018. — 231 p. — ISBN: 978-0-12-804667-8. In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such methodologies. The current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in...
Wiley, 2018. — 436 p. — (Wiley Series on Technologies for the Pharmaceutical Industry). — ISBN: 9781119282563. A key resource for toxicologists across a broad spectrum of fields, this book offers a comprehensive analysis of molecular modelling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals. Provides a perspective of what is...
John Wiley & Sons, Inc., 2007. — 854 p. — ISBN: 0470049626. This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer–based tools utilizing X–ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) models of human proteins Introduction to...
Taylor & Francis Group. Boca Raton London New York, 2007. — 950 p. Biomedical sciences’ use of animals as models to help understand and predict esponses in humans, in toxicology and pharmacology in particular, remains both the major tool for biomedical advances and a source of significant controversy. Every section has been updated, and more guidance has been directed to...
Hoboken: John Wiley & Sons, 2008. – 1057 p. This Preclinical Development Handbook: Toxicology focuses on the methods of identifying and understanding the risks that are associated with new potential drugs for both large and small therapeutic molecules. This book continues the objective behind this entire Handbook series: an attempt to achieve a through overview of the current...
2nd Edition. — Academic Press, 2019. — 1170 p. — ISBN: 978-0-12-814655-2. This book, Second Edition, is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This revised and completely updated edition includes both vertebrate and non-vertebrate species models for toxicological...
2nd edition. — Informa Healthcare, 2006. — 517 p. — ISBN: 9780849338588 Furnishing essential data on all areas of toxicity testing, this Second Edition provides guidance on the design and evaluation of product safety studies to help ensure regulatory acceptance. Every chapter highlights regulatory requirements specific to the United States, Europe, and Japan, and in addition to...
ISBN: 0-8247-0073-2 David Jacobson-Kram, Ph.D., D.A.B.T. Vice President, Toxicology and Laboratory Animal Health Division, BioReliance Corporation, Rockville, Maryland. Kit A. Keller, Ph.D. Toxicology Consultant, Washington, D.C. Copyright. 2001 by Marcel Dekker, Tnc. All Rights Reserved. Use of Laboratory Animals in Toxicology Studies Toxicity Associated with Single Chemical...
Monograph. — West Kazakhstan Marat Ospanov State Medical University. Ministry of Healthcare and Social Protection of the Republic of Kazakhstan. — Aktobe: [s. n.], 2014. — 138 p. — ISBN: 5-628-00998-9. The book systematizes literature data and the results of in-house research in toxicology of inorganic phosphates and fluorides. It shows the modes of action of a yellow and red...
Springer, 2025. — 308 p. The book explores the role of flow cytometry in varied fields, from clinical diagnosis to toxicology. This comprehensive book offers insights into biomarkers, cellular analysis, and safety evaluations. Organized into fifteen chapters, this book explores flowcytometry's historical journey, scientific validation, and implementation in toxicity studies...
Springer, 2023. — 1160 p. — (Biomarkers in Disease: Methods, Discoveries and Applications). — ISBN 978-3-031-07391-5. This handbook of the series Biomarkers in Disease informs comprehensively about all aspects of monitoring and detecting toxicity in the human body and model organisms. Biomarkers for assessing toxicity in diverse organs are presented and different assays and...
Academic Press, 2016. — 448 p. — ISBN 978-0-12-800764-8. Genetic Toxicology Testing: A Laboratory Manual presents a practical guide to genetic toxicology testing of chemicals in a GLP environment. The most commonly used assays are described, from laboratory and test design to results analysis. In a methodical manner, individual test methods are described step-by-step, along...
New York: Chapman and Hall/CRC, 2020. — 287 p. Statistical Models in Toxicology presents an up-to-date and comprehensive account of statistical theory topics that occur in toxicology. The attention given by statisticians to the problem of health risk estimation for environmental and occupational exposures in the last few decades has created excitement and optimism among both...
Springer International Publishing AG, 2017. — 330 p. — (Advances in Biochemical Engineering/Biotechnology 157) — ISBN: 3319459066. This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics,...
Taylor & Francis, 2006. - 394 p. Introduction and Overview. New concepts and approaches. Toxicogenomics: Gene Expression Analysis and Computational Tools. Proteomics. The Potential of Metabonomics in Toxicology. Quantitative Structure–Toxicity Relationships Using Chemodescriptors and Biodescriptors. Hormesis: A Key Concept in Toxicology. Integration Into Practice. Chemical Risk...
М.: Медицина, 2009. — 208 с. — ISBN 5-225-03412-8. В монографии рассмотрены теоретические, методические и прикладные аспекты проблемы экстраполяции токсикологических данных с животных на человека в различных областях гигиены, фармакологии и экспериментальной медицины. Работа построена на анализе обширных литературных данных и материалов собственных исследований. Изложены...
Нижний Новгород: ННГУ, 1997. — 156 с. В книге приведены в историческом и сравнительном плане известные авторам методы расчета средне-эффективных доз и дан их анализ с позиций современных представлений математической статистики. Эффективная доза как статистические показатель. Категории эффективных доз (понятия, определения, термины) Анализ методов расчета эффективных доз с позиций...
М.: Медицина, 2008. — 288 с.
В книге изложены существующие и авторские разработки, касающиеся проблемы оценки зависимости проявления эффектов от доз исследуемых агентов. В качестве исходных данных использованы результаты независимых единичных испытаний (без формирования групп с одинаковыми дозовыми нагрузками); функции эффективности любого вида построены непосредственно по...
Уфа: Изд-во БГПУ, 2009. — 128 с. В книге приводятся результаты, полученные при исследовании крыс и обследовании рабочих, находившихся в условиях интоксикации гербицидом 2,4-ДА. В данных исследованиях были выявлены отрицательные изменения показателей омега-потенциала головного мозга и периферической крови. Метод изучения омега-потенциала головного мозга и периферической крови...
Казань: Издательство Казанского университета, 2023. — 108 с. — ISBN 978-5-00130-704-4. Воздействие ксенобиотиков разнообразного происхождения на биосферу Земли, в том числе биологические объекты, многогранно и значительно. Несмотря на существенные достижения различных сфер биологической науки, вопросы цитопатологической направленности о влиянии ксенобиотиков на животных с...
М.: Медицина, 1970. - 344 с.
Токсикометрия представляет собой экспериментальный раздел токсикологии, образующий методологический фундамент всей этой науки. В книге разбираются основные понятия токсикологии, принципы и методы установления ПДК, методы постановки токсикологических экспериментов на различных видах животных, способы оценки кумулятивных свойств веществ. Отдельные...
Учебное пособие. — Уфа: БГМУ, 2012. — 113 с. Учебное пособие «Механизмы и методы оценки цитотоксичности» подготовлено в соответствии с рабочей программой элективного курса «Современные достижения генетики», составленной согласно ФГОС (2010 г.) по дисциплине биология для студентов, обучающихся по специальностям: «Лечебное дело», «Педиатрия», «Стоматология»,...
Воронеж: Истоки, 2013. — 46 с. — ISBN: 978-5-88242-992-7 Предназначено для научных работников, студентов, аспирантов и преподавателей ВУЗов биологического и зооветеринарного профиля. Введение Биотрансформация ксенобиотиков Общие представления о механизмах биотрансформации Реакции I фазы метаболизма Реакции II фазы метаболизма Ферменты, метаболизирующие ксенобиотики Семейство...
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