The Royal Society of Chemistry, 2019. — 564 p. — (Drug Discovery Series 68). — ISBN-13 9781788012096. The sequencing of the human genome and subsequent elucidation of the molecular pathways that are important in the pathology of disease have provided unprecedented opportunities for the development of new therapeutics. Nucleic acid-based drugs have emerged in recent years to...
Springer, 2013. — 63 p. — (SpringerBriefs in Biochemistry and Molecular Biology). — ISBN 978-3-0348-0678-7. Нетранслируемые области генов и другие некодирующие элементы: регуляция экспрессии эукариотических генов There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding...
University Science Books, 2000. - 821 p. - ucleic Acids presents an up-to-date and comprehensive account of the structures and physical chemistry properties of nucleic acids, with special emphasis on biological function. With a targeted audience of 1)molecular biologists, 2)physical biochemists, and 3)physical chemists, the book has been carefully organized to reach three...
University Science Books. 2000. 820 p. Bases, Nucleosides, and Nucleotides Chemical and Enzymatic Methods Nucleic and Structures from Diffraction Methods Structure and Dynamic by NMR Electronic and Vibrational Spectroscopy Theoretical Methods Conformational Changes Size and Shape of Nucleic Acids in Solution Supercooled DNA Interaction of Nucleic Acids and Water and Ions...
Wiley-VCH Verlag GmbH & Co. KGaA, 2003. — 732 p. — ISBN: 3-527-30595-5 OCR
The ultimate goal of most organic-medicinal chemists is to see the small molecule that they have synthesized become a useful drug for the treatment of human diseases. Unfortunately, even with modern technology this is an extremely rare event. In most cases, the compounds designed and synthesized...
Wiley-VCH Verlag GmbH & Co. KGaA, 2003. — 732 p. — ISBN: 3-527-30595-5
The ultimate goal of most organic-medicinal chemists is to see the small molecule that they have synthesized become a useful drug for the treatment of human diseases. Unfortunately, even with modern technology this is an extremely rare event. In most cases, the compounds designed and synthesized (generally...
RSC. 2004. 196 p.
The Biological Roles of the Nucleic Acids
The Covalent Structures of Nucleic Acids
The Three-Dimensional Structure of DNA and its Implications for Replication
Transcription and Translation of the Genetic Message
Modern Tools of DNA Analysis
Answers to Problems
Oxford University Press. 1997. 192 p.
Part 1: Nucleosome Dynamics and Transcription
Nucleosomes, dynamic repressors of transcription
Role of a positioned nucleosome in constitutive repression and hormone induction of the MMTV promoter
Histone modification and transcriptional competence
Mechanisms for alleviating chromatin-mediated repression of transcription
Part 2:...
Springer, 2014. - 599 p. - This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular...
Wiley, 2010. - 473 p. - Bringing the power of biochemical analysis to toxicology, this modern reference explains genotoxicity at the molecular level, showing the links between a DNA lesion and the resulting cellular or organismic response. Clearly divided into two main sections, Part 1 focuses on selected examples of important DNA lesions and their biological impact, while the...
Springer, 2017. — 304 p. — ISBN10: 3319502883, 13 978-3319502885. For several years, researchers have been reporting the effects of microwave radiation/heating on both the structure and function of DNA, RNA and proteins. For the most part, favourable accelerated biological functions are observed as microwave induced heating occurs, but other not-so favourable effects are also...
Boca Raton: CRC Press, 1998. — 749 p. This comprehensive yet balanced work emphasizes the principles and rationale underlying recombinant DNA methodology while furnishing a general understanding of the experimental protocols-suggesting flexible approaches to resolving particular molecular necessities that are easily adaptable to readers' specific applications. Features summary...
Springer, 2016. - 548 p. This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to...
Wiley-VCH Verlag GmbH & Co. KGaA, 2005. — 931 p. — ISBN: 3-527-30826-1; Vol. 1, 2 Фундаментальная работа по биохимии рибонуклеиновых кислот в двух томах Первый том - синтез, определение структуры Второй том - геномика, функции
2nd Edition. - Wiley, 2014. - 1371 p. - The second edition of a highly acclaimed handbook and ready reference. Unmatched in its breadth and quality, around 100 specialists from all over the world share their up-to-date expertise and experiences, including hundreds of protocols, complete with explanations, and hitherto unpublished troubleshooting hints. They cover all modern...
Elsevier, 2013. - 356 p. - Advances in Protein Chemistry and Structural Biology, V
92. - Published continuously since 1944, Advances in Protein Chemistry and Structural Biology has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and...
The Royal Society of Chemistry, 2008. - 273 p. - This book sets out to guide the analyst through the steps needed to obtain good quality results in DNA analysis. The underlying principles for achieving this goal were formulated by LCG as the six principles for ensuring valid analytical measurement, which are detailed in the introduction. The authors of each chapter are...
Published Online: 6 JUN 2006 Print ISBN: 9783527310593 Online ISBN: 9783527608195 DOI: 10.1002/3527608192 http://onlinelibrary.Wiley.com/book/10.1002/3527608192 The Aptamer Handbook, leading scientists from academia as well as biotech and pharma companies introduce the revolutionary concept of designing RNA and DNA oligonucleotides with novel functions by in vitro selection....
2nd ed. , Wiley, 2001. – 506 p.
This book is based on lectures on regulation and signal transduction that are offered to students of biochemistry, biology and chemistry at the University of Bayreuth. During the pre paration of these lectures I realized that it is extremely difficult to achieve an overview of the area of signal transduction and regulation. Our knowledge of signal...
ExLi4EvA, 2016. - 219 p. - This book contains a series of chapters that highlight the development and status of the various aspects of the nucleic acids related to DNA chemistry and biology and the molecular application of these small DNA molecules and related synthetic analogues within biological systems. The information in the present book will be of value to those directly...
CRC Press, 2009. — 571 p. The Handbook of Nucleic Acid Purification provides researchers and students with an all-encompassing volume on nucleic acid extraction strategies. Due to the complexities within prokaryotic and eukaryotic cells, purification of the nucleic acids often forms a vital first step in the study of molecular biology of living organisms as well as in the...
Wiley. 2010. 496 p. With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: *chemical synthesis of modified RNA* expansion...
Cambridge University Press, 1987. - 234 p. This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods...
Academic Press, 2008. — 289 р. — ISBN 978-0-12-369507-9. The aim of the book is to provide an introduction to the underlying fundamental features and principles governing nucleic acid structures, as well as many of the structures themselves. The book emphasizes those structures determined by X-ray crystallography, since this methodology continues to dominate the field in terms...
Oxford University Press, 1999. — 662 p. The book is a comprehensive reference text on all aspects of nucleic acid sturcture. Particular emphasis is placed on the results from X-ray crystallography and NMR studies, with both methods being given equal weight. The nineteen chapters describe in detail the variety of DNA and RNA structural types discovered to date with all the major...
Springer, 2024. — 185 p. The book provides a concise, integrated view of DNA biology and biotechnology in various aspects, such as human health, food production, environmental sustainability, and industry development. It covers the evolution of DNA, genes, cancer, aging biology, and plant gene technology. The chapters delve into the evolution of DNA, cells, genes, and...
Springer, 1984. - 574 p. - New textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical ther modynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially...
Springer, 2020. — 129 p. — (Advances in Biochemical Engineering/Biotechnology 170). — ISBN: 978-3-030-29645-2. This volume reviews numerous reaction mechanisms and applications of nucleic acids with catalytic activity. Written by an interdisciplinary team of authors, it provides an essential overview of these acids’ fundamental aspects, while also addressing associated...
Taylor & Francis Group, 2006. - 896 p. - Stands as the most comprehensive guide to the subject—covering every essential topic related to DNA damage identification and repair. Covering a wide array of topics from bacteria to human cells, this book summarizes recent developments in DNA damage repair and recognition while providing timely reviews on the molecular mechanisms employed...
Plenum Press, 1986. - 567 p. - This book is based on the papers presented at the conference on "Mecha nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment," held at the National Bureau of Standards on June 2-7, 1985, This volume deals with mechanisms of DNA damage and repair at the molecular level; consequences of unrepaired or misrepaired damage,...
Academic Press, 1994. - 407 p. - DNA Structure and Function, a timely comprehensive resource, is intended for any student or scientist interested in DNA structure and its biological implications. This book provides a simple yet comprehensive introduction to nearly all aspects of DNA structure. It also explains current ideas on the biological significance of classic and alternative...
Springer, 2006. - 523 p. - Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA. Free-radical DNA damage may lead to mutations, cancer, and cell death. Free radicals have various sources, notably ionizing radiation and...
Springer, 2023. — 2847 p. This handbook is the first to comprehensively cover nucleic acids from fundamentals to recent advances and applications. It is divided into 10 sections where authors present not only basic knowledge but also recent research. Each section consists of extensive review chapters covering the chemistry, biology, and biophysics of nucleic acids as well as...
The Royal Society of Chemistry, 2006. - 271 p. - The binding of antibiotics and drugs to DNA is a fast developing area of research with important applications in medicine, particularly the treatment of cancer. Sequence-specific DNA Binding Agents uniquely discusses key aspects of this topic, providing a novel perspective on the subject. Written by experts in the field, this book...
М.: Мир, 1976. — 415 с. OCR. Небольшая монография Дэвидсона выдержала в Англии за 22 года 7 изданий (русский перевод 1-го издания - ИЛ, 1952). Последнее, 7-е издание - совершенно новая книга, в которой, несмотря на небольшой объем, автору удалось обобщить все, что известно о нуклеиновых кислотах. Отдельные главы посвящены истории открытия нуклеиновых кислот, строению их...
7-е изд. — Пер. с англ. канд. физ.-мат. наук В.В. Борисова; Под ред. акад. А.А. Баева. — М.: Мир, 1976. — 412 с. Небольшая монография Дэвидсона выдержала в Англии за 22 года 7 изданий (русский перевод 1-го издания - ИЛ, 1952). Последнее, 7-е издание — совершенно новая книга, в которой, несмотря на небольшой объем, автору удалось обобщить все, что известно о нуклеиновых...
М.: Химия, 1970. — 720 с., 108 таблиц, 78 рисунков В книге систематизированы данные по органической химии нуклеиновых кислот и их компонентов - гетероциклических оснований, углеводных остатков и фосфатных групп. Основное внимание уделено строению, физико-химическим свойствам и реакционной способности компонентов нуклеиновых кислот. Рассмотрены основные реакции, используемые при...
М.: Химия, 1970. — 720 с., 108 таблиц, 78 рисунков В книге систематизированы данные по органической химии нуклеиновых кислот и их компонентов - гетероциклических оснований, углеводных остатков и фосфатных групп. Основное внимание уделено строению, физико-химическим свойствам и реакционной способности компонентов нуклеиновых кислот. Рассмотрены основные реакции, используемые при...
СПб: Эко-Вектор. — 2017. — (Учебное пособие). — 288 с. — ISBN 978-5-906648-29-7. Настоящее издание представляет собой учебное пособие, предназначенное для студентов и аспирантов, специализирующихся в области молекулярной биологии и генетики. В нем освещены проблемы, связанные с биогенезом и функциями одного из основных биологических полимеров - РНК. Рибонуклеиновая кислота, или...
СПб: Эко-Вектор. — 2017. — (Учебное пособие). — 288 с. — ISBN 978-5-906648-29-7. Настоящее издание представляет собой учебное пособие, предназначенное для студентов и аспирантов, специализирующихся в области молекулярной биологии и генетики. В нем освещены проблемы, связанные с биогенезом и функциями одного из основных биологических полимеров - РНК. Рибонуклеиновая кислота, или...
Аппель Б., Бенеке Б.-И., Бененсон Я. и др.; пер. с англ. - М.: БИНОМ. Лаборатория знаний, 2013. - 413 с.
В справочном издании, написанном интернациональным коллективом, рассмотрены практически все аспекты, связанные со строением, синтезом, модификацией, функционированием ДНК и РНК. Дано подробное описание биохимических механизмов и процессов, сопровождаемое рисунками, схемами и...
ООО Цифровичок г. Москва, 2015. — 100 с. Особое место в науке о живом занимают нуклеиновые кислоты. Собственно само возникновение целых областей биоорганической химии, молекулярной биологии, биомедицинской химии и др. обязано работам, связанным с изучением нуклеиновых кислот. Именно в этой области сделаны открытия, позволившие расшифровать механизм важнейшей стороны жизни –...
Конспект лекций. – Бийск: Изд-во Алт. гос. техн. ун-та, 2017. – 80 с. В конспекте лекций представлены основные сведения по химии азотистых оснований нуклеиновых кислот. Показаны пути биосинтеза и направления использования производных пуриновых и пиримидиновых соединений. Пособие предназначено для студентов и магистрантов, обучающихся на кафедре «Биотехнология» Бийского...
Уфа: Институт биохимии и генетики Уфимского научного центра РАН, 2002. — 80 с. За более чем столетнюю историю изучения о ДНК накоплена масса сведений, часть из которых нашли свое отражение в данной брошюре. Наибольшее внимание уделено результатам исследований последних десятилетий, ставших возможными благодаря открытию двойной спирали ДНК, разработке методов клонирования,...
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