Masters B.R., So P. Handbook of Biomedical Nonlinear Optical Microscopy

Oxford University Press, 2008. - 860 p. - The Handbook of Biomedical Nonlinear Optical Microscopies provides comprehensive treatment of the theories, techniques, and biomedical applications of nonlinear optics and microscopy for cell biologists, life scientists, biomedical engineers, and clinicians. The chapters are separated into basic and advanced sections, and provide both textual and graphical illustrations of all key concepts. The more basic sections are aimed at life scientists without advanced training in physics and mathematics, and tutorials are provided for the more challenging sections. The first part of the Handbook introduces the historical context of nonlinear microscopy. The second part presents the nonlinear optical theory of two- and multiphoton excited fluorescence (TPE, MPE) spectroscopy, second and third harmonic generation (SHG, THG) spectroscopy, and coherent anti-Stokes Raman spectroscopy (CARS). The third part introduces modern microscopic and spectroscopic instrumentation and techniques that are based on nonlinear optics. The fourth part provides key applications of nonlinear microscopy to the biomedical area: neurobiology, immunology, tumor biology, developmental biology, dermatology, and cellular metabolism. There are also chapters on nonlinear molecular probes, cellular damage, and nanoprocessing.List of Contributors
Foreword
Historical Development of Nonlinear Optical Spectroscopy and Microscopy
Introduction: Historical Development of Nonlinear Optical Microscopy and Spectroscopy
The Genesis of Nonlinear Optical Microscopies and Their Impact on Modern Developments
The Scientific Life of Maria Göppert-Mayer
The History of Perturbation Theory from Astronomy to Quantum Mechanics
English Translations of and Translator's Notes on Maria Göppert-Mayer's Theory of Two-Quantum Processes
Nonlinear Optical Spectroscopy
Introduction: Nonlinear Optical Spectroscopy, Classical and Quantum Theory of One-Photon and Multiphoton Fluorescence Spectroscopy
Second- and Higher-Order Harmonic GenerationTheory of Spontaneous and Coherent Raman Scattering
Nonlinear Optical Instruments for Microscopic Imaging and Analysis
Introduction: Nonlinear Optical Instruments for Microscopic Imaging and Analysis: Review and Forecast
Laser Sources for Non-Linear Microscopy
Ultrashort Optical Pulse Delivery for Nonlinear Optical Microscopy
An Optical Design Primer for Nonlinear Optical Microscopy
Image Formation in Multiphoton Fluorescence Microscopy
Signal Detection and Processing in Nonlinear Optical Microscopes
Multiphoton Excitation of Fluorescent Probes
Multiphoton-Induced Cell Damage
Applications of Second-Harmonic Generation Microscopy
Second-Harmonic Generation Imaging Microscopy of Structural Protein
Coherent Anti-Stokes Raman Scattering (CARS) Microscopy: Instrumentation and Applications
High-speed Imaging Using Multiphoton Excitation
Nonlinear Multi-Spectral Optical Imaging Microscopy: Concepts, Instrumentation, and Applications
Multiphoton Polarization MicroscopyLifetime-Resolved Imaging in Nonlinear Microscopy
Förster Resonance Energy Transfer (FRET) Microscopy
Diffraction Unlimited Far-Field Fluorescence Microscopy
Two-Photon Fluorescence Correlation Spectroscopy
Photobleaching and Recovery with Nonlinear Microscopy
Femtosecond Laser Nanoprocessing
Biomedical Applications of Nonlinear Optical Microscopy
Introduction: Biomedical Applications of Nonlinear Optical Microscopy
Pioneering Applications Of Two-Photon Microscopy To Mammalian Neurophysiology: Seven Case Studies
Applications of Non-Linear Intravital Microscopy in Tumor Biology
Immunology Based on Nonlinear Optical Microscopy
Multiphoton Imaging in Animal Development
Nonlinear Microscopy Applied to Dermatology
Cellular Metabolism Monitored by NAD(P)H Imaging with Two-Photon Excitation Microscopy