Thassu D., Deleers M., Pathal Y. (Eds.) Nanoparticulate Drug Delivery Systems

Informa Healthcare USA, Inc., USA, 2007. — 382 p. — (Drugs and the Pharmaceutical Sciences 166) — ISBN: 978-0849390739The use of molecular or macromolecular entities and superstructures derived thereof for the delivery of drugs has a long history. Antibodies, for instance, were suggested early last century as a means to direct anticancer drugs to tumor cells in the body expressing the corresponding antigen. Their use in the form of monoclonals is now at the forefront of targeted therapy. Following advances in the discovery of cell receptors, receptor-binding macromolecules were added to the armamentarium of systems for the targeting of drugs. Parallel to these developments has been, since the early 1970s, the exploitation of liposomes as a delivery system for drugs and vaccines. These superstructures, formed spontaneously from amphipathic lipid molecules, together with a diverse collection of other promising superstructures derived from a huge variety of natural and synthetic monomeric or polymeric units, have evolved to sophisticated versions through the incorporation onto their surface of macromolecules that contribute to optimal pharmacokinetics of actives and their delivery to where they are needed. An ever increasing number of drug- and vaccinedelivery systems are being tested clinically, with many already marketed.Nanoparticulate Drug-Delivery Systems: An Overview
Nanosuspensions for Parenteral Delivery
Nanoparticles Prepared Using Natural and Synthetic Polymers
Nanofiber-Based Drug Delivery
Drug Nanocrystals—The Universal Formulation Approach for Poorly Soluble Drugs
Lipid-Based Nanoparticulate Drug Delivery Systems
Nanoengineering of Drug Delivery Systems
Aerosol Flow Reactor Method for the Synthesis of Multicomponent Drug Nano- and Microparticles
Supercooled Smectic Nanoparticles
Biological and Engineering Considerations for Developing Tumor-Targeting Metallic Nanoparticle Drug-Delivery Systems
Biological Requirements for Nanotherapeutic Applications
Role of Nanobiotechnology in the Development of Nanomedicine
Pharmaceutical Applications of Nanoparticulate Drug-Delivery Systems
Lipid Nanoparticles (Solid Lipid Nanoparticles and Nanostructured Lipid Carriers) for Cosmetic, Dermal, and Transdermal Applications
Nano-Carriers of Drugs and Genes for the Treatment of Restenosis
Ocular Applications of Nanoparticulate Drug-Delivery Systems
Nanoparticulate Systems for Central Nervous System Drug Delivery
Nanoparticles for Gene Delivery: Formulation Characteristics
Gastrointestinal Applications of Nanoparticulate Drug-Delivery Systems
Nanoparticles as Adjuvant-Vectors for Vaccination
Transdermal Applications of Nanoparticulates