Guo P., Haque F. (Eds.) RNA Nanotechnology and Therapeutics

Taylor & Francis Group, 2014. — 613 p.Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown. Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in the biophysical and single molecule approaches in RNA nanotechnology. In addition, the text also provides in-depth discussions of RNA structure for nanoparticle construction, RNA computation and modeling, single molecule imaging of RNA, RNA nanoparticle assembly, RNA nanoparticles in therapeutics, RNA chemistry for nanoparticle synthesis, and conjugation and labeling.Contents
Introduction: Principles and Fundamentals of RNA Nanotechnology
The Emerging Field of RNA Nanotechnology
Uniqueness, Advantages, Challenges, Solutions, and Perspectives in Therapeutics Applying RNA Nanotechnology
RNA Folding, Structure, and Motifs in RNA Nanoparticle Assembly
Kink Turn Structural Motif in RNA
RNA Nanotechnology: Learning from Biologically Active RNA Nanomachines
Natural Selection and Structural Polymorphism of RNA 3D Structures Involving GNRA Loops and Their Receptor Motifs
RNA Junction Motifs as Scaffolds for Construction of Multifunctional RNA Nanoparticles
RNA Computation and Structure Prediction for RNA Nanoparticle Construction
Role of Dynamics in RNA Nanostructure Design
RNA Three-Dimensional Structure Determination Using Experimental Constraints
RNA Chemistry for Nanoparticle Synthesis, Conjugation, and Labeling
Nucleotide Chemistry for RNA Nanoparticle Labeling, Conjugation, and Synthesis
RNA Conjugations and Ligations for RNA Nanotechnology
Atom-Specific Mutagenesis of RNAs for Structure, Function, and Therapeutics Studies
Single-Molecule and Biophysical Techniques in RNA Nanostructure Analysis
Atomic Force Microscopy of RNA: Imaging and Beyond
Single-Molecule Approach to Study RNA Nanoparticles
Methods for the Assembly of RNA Nanoparticles
Fabrication Methods for RNA Nanoparticle Assembly Based on Bacteriophage phi29 Packaging RNA Structural Features
Synthetic RNA–Protein Nanostructures and Their Potential Applications
DNA Nanotechnology as Reference for RNA Nanotechnology
RNA Nanoparticles for Therapy of Cancer, Viral Infections, and Genetic Diseases
Thermodynamically Stable RNA Three-Way Junction for Constructing Multifunctional Nanoparticles for Delivery of Therapeutics
Design and Construction of RNA Nanoparticles Targeting Prostate Cancer
Conjugation of RNA Aptamer to RNA Nanoparticles for Targeted Drug Delivery
Extracellular Membrane Vesicles and Extracellular Membrane Vesicle–Based Therapeutics for Brain Diseases
Pharmacokinetics and Pharmacodynamics of RNA Nanoparticles
RNA Nanotechnology for Diagnostic Applications
RNA Nanotechnology in Sensing, Detection, and Disease Diagnosis
Potentials of RNA Aptamers for Viral Detection and Treatment
Application of RNA Aptamers in RNA Nanotechnology and Therapeutics
Application of RNA Aptamers in Nanotechnology and Therapeutics
Aptamers Targeting a Subunit or a Conformation of Glutamate Ion Channel Receptors
Application of miRNAs in RNA Nanotechnology and Therapeutics
Application of MicroRNAs in RNA Nanotechnology and Antiviral Therapeutics
MicroRNAs: Biology and Role in RNA Nanotechnology
Application of siRNAs in RNA Nanotechnology and Therapeutics
Current Advances in Self-Assembly RNAi Nanoparticles
Self-Assembly of siRNA Containing Nanoparticles